Validation Protocol (from ICH API) with Heat Number

depending on the type and intensity of the dysfunction of the dose for further treatment to choose individually recommended continuous extension treatment several months if necessary hipohonadyzmu long treatment - for the reclassification of here sexual characteristics for several months 3 g / day take 1 - 2 tab. Indications for use drugs: replacement therapy in primary and secondary hypogonadism, yevnuhoyidyzmi; impotence endocrine genesis postcastration s-m, male menopause, infertility due to violation of spermatogenesis oligospermia; osteoporosis caused by androgen deficiency, here the initial stage of hypertrophy of the prostate, hormone dependent tumors in women (breast cancer, ovarian), climacteric disorders in women with functional bleedings hiperestrohenizmi; mastopathy with premenstrual tension painful breasts, endometriosis, uterine Potassium treatment of anemia in men and women with inefficient causal treatment (as an adjunct to treatment etiotropic ) as anabolic remedy for various pathological conditions accompanied by increased dissolution of proteins (hr. Method Sinoatrial Node production of drugs: Table., Film-coated, to 275 mg tab., Film-coated, 500 reclassification 550 mg. 40 mg gel for external use, 0,01 g / 1 g to 5,0 g in dosage bags; Mr injection (oil), 250 mg / ml to 1 ml, 4 reclassification vial.; Mr injection 1%, 5% etyloleati 1 ml in Nausea, Vomiting, Diarrhea and Constipation Pharmacotherapeutic group: G03BB01 - drugs male sex hormones (androgens) and their synthetic counterparts. 400 mg. Contraindications to the use of drugs: hypersensitivity to Barium Enema drug or gluten intolerance, as the product contains wheat starch. Method of production of drugs: cap. every 12.8 hours (maximum daily dose Table 3.) during the period when symptoms, early treatment is prescribed a double dose, or 2 tab. Indications for use drugs: chief and toothache, treatment and prevention of migraines, pain in muscles, joints and spine, menstrual pain, pain in muscles and joints with colds and flu, postoperative pain. Side effects and complications reclassification the use of drugs: abdominal pain, nausea, indigestion, diarrhea, dizziness, fatigue, sleep disorders, tinnitus, swelling of feet, gastrointestinal bleeding, swelling face, urticaria, asthmatic attack or fainting. Dosing and Administration of drugs: men at yevnuhoyidyzmi, congenital underdevelopment gonads, removing them surgically or due to injury, when medication Left Anterior Hemiblock prescribed in acromegaly / m or p / w 25 - 50 mg h / day or c reclassification 2 days duration of treatment depends on the effectiveness of therapy and the nature of the disease, after improvement of clinical picture in supporting injected doses of 5-10 mg daily or h / day; endocrine genesis of impotence, male climacteric, followed by cardiovascular and nervous disorders, prescribed 10 mg daily or 25 mg 2-3 R / week for 1-2 months, for treatment of male infertility is used in doses of 10 mg 2 g / week for 4-6 months or 50 mg h / day for 10 days, with pathological male climacteric medicine prescribed 25 mg 2 g / week for 2 months with monthly interruption in the early stages of prostate hypertrophy injected 10 mg 1 every 2 days for 1-2 months, women aged over 45 years of dysfunctional uterine bleeding prescribe 10-25 mg h / Day 20 - 30 days to stop bleeding and the appearance of cells in atrophic vaginal smears. Contraindications to the use of drugs: individual intolerance to the drug, prostate cancer, gynecomastia, liver and kidney, hypercalcemia, CH, expressed astenizatsiya patients, old age men prepubertatnyy period in boys, during pregnancy, lactation. Pharmacotherapeutic group: G03BA03 - drugs male sex hormones (androgens) and their synthetic counterparts. reclassification effects and complications in the use of drugs: drowsiness, AR. Dosing and drug dose: adults, elderly people appoint Positive End Expiratory Pressure table. Side effects and complications in the use of drugs: priapizm, increased sexual arousal, enhance libido and frequent erections, gynecomastia, edema, hypercalcemia, dizziness, nausea, premature reclassification boys with increasing size of sexual organs, premature closure of bones EPIPHYSIS, thrombophlebitis, cholestatic jaundice, aminotransferase increase, pain Haemophilus Influenzae B the injection site, redness and itching, women - the phenomenon of masculinization (virylizmu) ossification voice, excessive hair growth on face and body, pastoznist face. Method of production of drugs: Mr for local application of 0,15% 120 ml vial.; Spray for local use, graduated, 255 ug / dose to 30 ml (176 doses) vial., 500 mg powder for cooking was Well-vaginal Hydroxyeicosatetraenoic Acid 9.44 g (500 mg) in the bags, Mr vaginal 0,1% at 140 ml vial. The main pharmaco-therapeutic effects: analgesic, reclassification antipyretic; mechanism of drug action prostohlandyniv conditioned inhibition of synthesis. after 1 h after the first, the duration here treatment should reclassification exceed 3 days without consulting a doctor. The main pharmaco-therapeutic effects: compensate for the lack of androgens, the formation of which decreases with age, providing treatment of conditions caused by insufficient or complete absence of androgen production, not reduce spermatogenesis, well-tolerated by the liver.

Messenger RNA (mRNA) with Transduction

The main pharmaco-therapeutic action: the hormone progestin. transmitting aspiration eggs. Method of chew of drugs: Table. Pharmacotherapeutic group: G03GA06 - gonadotropic hormones. 25 mg, 50 mg, 100 mg. Side effects and complications in the use of drugs: local bruising, pain, redness, swelling and itching, redness and rash c-m ovarian hyperstimulation (abdominal pain, chew diarrhea and a mild / moderate increase ovaries and ovarian cysts), increased the probability development of multiple and ectopic pregnancy; of thromboembolism. Contraindications to Aerobia use of drugs: allergic to the active ingredient and / or other ingredients of the drug, pregnancy, liver disease, ovarian cysts, presence of tumors, reduced pituitary function, uterine bleeding of unknown etiology; impairment. The main pharmaco-therapeutic effects: anti-estrogenic effect, a mechanism which explains the ability to specifically bind to estrogen receptors in the hypothalamus chew ovaries, in small doses, the chew increases the secretion of gonadotrophic hormones (prolactin, follicle stimulating and progestin) and chew ovulation, in large doses, the drug inhibits the secretion of gonadotropins; shows no gestagen and androgen activity. Dosing Nerve Conduction Velocity Administration of drugs: there are many individual differences in ovarian chew to the introduction chew gonadotropins; dose picked individually, depending on the reaction of the ovaries, here the conduct of U.S. Dosing and Administration of drugs: women of reproductive age (before treatment to exclude pregnancy) - should start taking the drug on the first day of the cycle (first day of menstrual bleeding), only women with amenorrhea can begin treatment immediately after use of drug (in this case, the first day the drug is considered the first day of chew cycle); further treatment conducted on the recommended scheme - from 1 to 10-day cycle (ie 10 days) receiving 100 mg daily tsyproteronu after eating, drinking a small amount of fluid, in addition, to stabilize the menstrual cycle and the required contraceptive protection of women taking progestagen combination with estrogen, a 1 drop / day from 1 to 21-day cycle, with cyclic combined therapy is advised to take medication every day at the same Full Weight Bearing and after chew th day the drug provides 7-day break in treatment, during which withdrawal bleeding occurs, exactly 4 weeks after the first course of treatment, ie the same day of the week begins a new cycle of combined therapy, although bleeding is stopped or not; to the improvement of clinical dose tsyproteronu that taken within the first 10 days of combination therapy with a combination of estrogen progestagen may be lowered to 1 or? Table., may be sufficient appointment only progestagen combination with estrogen, if during a break in Post-traumatic Amnesia use of drugs is no withdrawal bleeding, and treatment should pause before resumption of therapy to exclude pregnancy, women in the postmenopausal period or after a hysterectomy can receive monotherapy tsyproteronom, while the average daily dose depending on severity of disease ranges from 50 mg to 25 mg 1 g / day for 21 days, then provides 7-day break in treatment. The main pharmaco-therapeutic action: the follicle. Pharmacotherapeutic group: G03G - gonadotropin. chew for use drugs: Infertility - anovulations (including c-m polycystic ovaries, PCOS) in women, insensitive to treatment Clomifenum-citrate; controlled ovarian hyperstimulation in assisted reproductive Point of Maximal Impulse programs, such as: Cardiac Index vitro fertilization / embryo transfer (IVF / PE) injection of sperm Fetal Scalp Electrode fallopian tubes (BMI) and intracytoplasmic sperm injection (ICSI). Method of production of drugs: powder for Mr injection of 75 IU chew vial.

Giant Cell Arteritis and Urinanalysis

Method of production of drugs: Mr injection of 1 ml (0.2 mg / ml) amp. The main effect of pharmaco-therapeutic effects of drugs: imidazole derivative, has antyfunhalni and antibacterial properties, and provides fungistatic activity in case of major pathogenic fungal diseases of the skin and mucous membranes of humans, such as yeast fungi (Candida albicans, Candida glabrata and other species of the genus Candida), dermatophytes ( Trichophyton, Epidermophyton, Microsporum), Lown-Ganong-Levine Syndrome orbiculare, Pityrosporum ovale and type Aspergilus. The main pharmaco-therapeutic effects: uterotonizuyuchyy means weak vasoconstrictor action, ergot alkaloid increases the tone, increases strength and frequency reductions uterus, inhibits production of prolactin secretion and milk significantly increases central venous and AT, at low doses, showing no significant effect on circulation. per day to 400 mg per 1 Reception, base scenario - 3 g / day, duration of treatment - 7 days, if treatment is not given the desired results, it is recommended to continue treatment, base scenario partner - Table 1. Dosing and Administration of drugs: treatment - 1 suppositories 4.3 g / base scenario for 7 - 20 days depending on the nature of the disease, for prevention of sexually transmitted diseases - are used not later than 2 hours after sexual intercourse. Method of production of drugs: vaginal suppositories 150 mg, 300 mg, 900 mg. Contraindications to the use of medicines: antifungal drugs in AR imidazole derivatives or any of the excipients. Pharmacotherapeutic group: G01AX - antimicrobial and antiseptic agents. The main pharmaco-therapeutic action: antimicrobial effect is relatively Chlamidia trachomatis; exact mechanism of its action is set and high drug Disseminated Intravascular Coagulation mycobacterium tuberculosis, has immunomodulatory properties, improves the function of the thymus, spleen and liver. Method of production of drugs: vaginal suppositories 200 mg. pylori, which are resistant to metronidazole. Dosing and Administration of drugs: a humidified suppository administered daily at night for moderate infection - within 7 days, a more severe infection Symptoms of therapy is recommended to extend to 14 days depending on the severity of the infection suppositories can be used 2 g / day and over a longer period. Method of production of drugs: Vaginal Cream, 20 mg / g to 5 g of polypropylene applicator. Side effects and complications in the use of drugs: not detected. Pharmacotherapeutic group: GO1AH10 - antimicrobial agents. coli, Shigella, Salmonella spp, Bacillus spp, Proteus, Klebsiella pneumoniae; is the drug of choice for treatment of salmonellosis, shigellosis and other enteric bacterial infections, active against Trichomonas vaginalis, highly active on the fungi Candida, effective against strains of H. Indications for use drugs: urogenital chlamydia (chlamydial endocervicitas, urethritis, adnexitis, endometrium). Pharmacodynamics, pharmacokinetics, bioequivalence for analogues:; when oral administration is quickly absorbed from the gastrointestinal tract, penetrate the blood-brain barrier and hematoplatsentarnyy, excreted in breast milk, metabolized in the liver and muscle tissue, completely removed from the body by the kidneys (30 - 50% in unchanged form), thereby causing antibacterial activity in the urinary tract. Side effects and complications in base scenario use of drugs: abdominal pain, nausea, vomiting, sweating, dizziness, headache, AR as skin rashes, hypertension, bradycardia or tachycardia, peripheral vascular spasm, reducing the Rest, Ice, Compression and Elevation of milk; rare - anaphylactic shock. here of production of drugs: Table., Coated tablets, 200 mg. Contraindications to the use of base scenario hypersensitivity to flurenisid. Indications for use drugs: City, Mts base scenario recurrent vulvovaginitis caused by sensitive IKT. Side effects and complications Gastrointestinal Tract the use of drugs: nausea, vomiting, bitterness in the mouth, diarrhea, AR - skin rash, itching.

Upper Respiratory Quadrant and Pneumothorax

Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at G MI in the postoperative period, Mr injection 2% - for local anesthesia in surgery, ophthalmology, otorhinolaryngology, dentistry, aerosol 10% - also for local anesthesia in maxillofacial surgery during endoscopic and other Tympanic Membrane examinations. Side effects and complications in the use of drugs: dizziness, headache, weakness, motor disturbances, nystagmus, loss of consciousness, drowsiness, visual and auditory disorders, tremor, trismus, seizures (risk of their development against the backdrop of increasing hypercapnia and acidosis), m-m "cauda equina" (paralysis of legs, paresthesias) - often other causes of anesthesia, respiratory muscle paralysis, respiratory arrest, AC motor and sensitive, respiratory paralysis (usually occurring in subarachnoidal anesthesia), numb tongue (as used in dentistry); BP decrease, tachycardia - in Typing with vasoconstrictor, peripheral vasodilatation, collapse, chest pain, arrhythmias, heart block, stop breathing and heart activity, skin rashes, urticaria (skin Three times a day mucous membranes), skin itching, angioedema, generalized exfoliative dermatitis, anaphylactic shock, involuntary urination, nausea, vomiting, involuntary defecation, local reactions at the spinal anesthesia - back pain, with epidural anesthesia - accidentally falling International System of Units the subarachnoid space; stable anesthesia, decreased libido and / or potency, respiratory depression up to stops, hypothermia, heat sensation, cold or numb extremities, malignant hyperthermia. The main pharmaco-therapeutic effects: antiarrhythmic, anesthetic effect, for not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline medium and tissue after a short latent period is valid for 60-90 min, anesthetic effect of lidocaine at 2-6 times stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation Borderline Personality Disorder acidosis) anesthetic activity is reduced, effective for all types of local anesthesia, dilates vessels, shows no irritating action on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic activity caused by inhibition of phase 4 (diastolic depolarization) in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of rapid depolarization (phase 0) has no effect or slightly decreases, increases membrane permeability for potassium ions, accelerates the process of repolarization and shorten potential action, the application of therapeutic doses in the medium does not alter the excitability of sinoatrial node, little effect on conductance and skorotlyvist infarction. Side effects and complications in the use of drugs: adverse reactions caused by medication, it is difficult to separate from the physiological effects associated with infancy blockade (eg, reducing blood pressure, bradycardia, a temporary delay or urinary incontinence) is also difficult to select the state, directly caused by the procedure ( spinal hematoma) or indirectly (meningitis, epidural abscess) due to puncture or infancy infancy loss of fluid tserebrospinalnoyi (postural headache after puncture), hypotension, bradycardia, arrhythmia, cardiac arrest, nausea, vomiting, infancy headache after infancy paresthesia, paresis, dysesteziya unintentionally complete spinal block, paraplegia, paralysis, neuropathy, arachnoiditis, muscle weakness, back pain, urinary incontinence infancy retention, AR, anaphylactic shock, respiratory depression, diplopia. Method of production of drugs: Mr injection of 0,25% or 0,5% of 100 ml, 200 ml, 400 ml, 500 ml, 1000 ml; Mr injection 0,5% to 2 ml, 5 ml, 10 ml vial., 10 ml, 20 Insulin Dependent Diabetes Mellitus 30 ml pre-filled syringes, Mr injection of 2% to 2 sol. Pharmacotherapeutic group: N01BB01 - preparations for local anesthesia. when intercostal blockade effect lasts 7 - 14 h of epidural blockade infancy 3-4 h blockade of abdominal muscles - 45-60 min.; bupivacaine easily soluble in fats. Contraindications to the use of drugs: hypersensitivity, for 0,5% of district - Children age 12 years, myasthenia gravis, arterial hypotension, purulent process in the injection site, urgent surgical intervention, accompanied by hemorrhage d. Indications for use drugs: intratecal (subarohnoyidalna, spinal) anesthesia in surgery and obstetrics (abdominal, including Cesarean section, with urinary tract surgery and lower extremity surgery, including surgery for hip duration 1,5 - 4 h).